Treatments that use components similar to human tissue, such as PN (Polynucleotide) extracted from salmon or collagen (Atelocollagen) derived from animal dermis, to indirectly trigger skin regeneration are collectively known as "skin boosters."
Re2O takes a fundamentally different approach from conventional skin boosters. Based on human-derived extracellular matrix (ECM), it does not indirectly trigger skin regeneration. It directly replenishes the core components that make up the skin.
Introducing Re2O, a skin booster that fills the skin directly with the components it needs.
Understanding the Principle of Re2O Through the Extracellular Matrix (ECM)
To explain how Re2O works, we first need to understand what the human skin is made of.
The core of skin aging and loss of elasticity lies not on the surface but in the dermal layer deeper within. The dermis is not made up of cells alone. It consists of a complex structure that densely fills and supports the spaces between cells, known as the Extracellular Matrix (ECM).
This ECM is composed of well-known elements such as collagen, elastin, hyaluronic acid that holds moisture, and proteoglycans. They maintain the thickness of the dermis, give it elasticity, and create an environment in which skin cells can function in a healthy state, serving as the essential framework of the skin.
As time passes and external stimuli accumulate, the ECM components that supported the dermis are gradually lost and broken down. Once-firm skin becomes thinner and weaker, elasticity declines, and inner dryness and fine lines noticeably increase. We refer to this series of phenomena, in which the structure of the dermal layer collapses, as aging.
Re2O steps directly into this aging process. Rather than animal-derived components, it uses Human Acellular Dermal Matrix (hADM), obtained by safely removing immune-response substances from human dermal components, and processes it into fine particles to replenish the ECM lost within the dermal layer. By doing so, it physically reinforces the thickness and density of the thinned dermis and restores the skin's original structural stability. This is the core principle of Re2O.
Conventional skin boosters were treatments designed to trigger skin regeneration. Re2O, on the other hand, is a treatment that directly fills the skin with components that benefit it. Even within the skin booster category, the term "skin supplement" may be a better fit for what it does.
Understanding the Safety of Re2O Through Human Acellular Dermal Matrix (hADM)
The core component of Re2O, Human Acellular Dermal Matrix (hADM), is highly biocompatible due to its human origin and has passed the rigorous raw material approval standards of the U.S. FDA. As a relatively recent addition to the skin booster category, its effects and safety are not yet widely known to the general public.
The technology behind Re2O is by no means new. Products using hADM have long been widely used in medical settings as skin grafting materials to restore skin defects from severe burns or soft tissue damaged by serious trauma.
Through the special Alloclean Technology process, Re2O thoroughly removes cells and immune-triggering substances that may cause rejection reactions, safely retaining only the pure foundational matrix (ECM) needed for skin reconstruction, and processes it finely and uniformly enough to be injected directly into the dermal layer.
The fact that it has been used for a long time in severe reconstructive fields cannot be unconditionally extended as proof of absolute safety. It is more accurate to say it is a treatment with relatively high safety because it minimizes immune responses.
The fact that it has been recently introduced within the skin booster category also means that even with the same treatment, safety and effectiveness can vary depending on how precisely and at what depth it is applied within the dermis. As a specialist in cell regeneration treatments, Maison Prive Clinic recommends a treatment cycle under the concept of "post-treatment" to make the most of Re2O. The method is as follows.
Effects and Treatment Cycle of Re2O
Maison Prive Clinic recommends Re2O as a post-treatment skin booster because of one unique trait: Re2O directly replenishes the extracellular matrix (ECM) of the skin.
Lifting treatments that apply strong heat or physical stimulation to the skin, such as Ulthera, Thermage, and thread lifting, work by prompting the skin to regenerate collagen on its own. They send the skin a powerful signal to produce collagen. Rather than aggressively performing another treatment immediately after when the skin is still sensitive, performing Re2O during the recovery period when the skin has calmed down and started a real regenerative response can be safer and more effective.
When core building materials like Re2O are supplied at the right moment to skin that has received powerful regenerative signals, an explosive synergy is created. The treatment cycles recommended by Maison Prive Clinic are as follows.
- Standalone Treatment: Performing Re2O on its own is also effective enough. Two treatments at one-month intervals are recommended, and the treatment time including anesthesia takes about one hour. To maintain the firmer dermis afterward, repeat treatment is recommended every 6 to 12 months.
- Post-Treatment: This is the treatment method Maison Prive recommends. After taking sufficient recovery time following treatments such as Ulthera, Thermage, or thread lifting, Re2O is performed at the optimal timing recommended by the medical team. This process maximizes the synergy of skin regeneration and helps the lifting effect last more firmly.
The preceding lifting treatment that creates the most ideal synergy with Re2O varies according to each individual's skin condition and needs. Designing a personalized Beauty-Aging plan based on accurate diagnosis from the medical team before treatment is the most important step of all.
A detailed approach according to the treatment area and purpose raises the quality of the treatment to a higher level. Re2O is applied for the overall elasticity and skin texture improvement of the face, while Re2O Fine, with its even more delicate particles, is applied to thin and sensitive areas such as around the eyes or under-eye lines, completing a more refined and smooth result.
The extracellular matrix (ECM) injected through Re2O densely rebuilds the framework of the depleted dermis and restores the collapsed structure of the skin. As the thickness and density of the dermal layer are fundamentally replenished, a healthy oil-moisture balance is restored, easing the inner dryness that cosmetics could rarely resolve. By firmly supporting skin tissue thinned by aging, fine lines are softened, and outstanding effects can be expected in enhancing the skin's inherent elasticity.
Through Re2O, which directly fills the structural gaps of the dermal layer, we invite you to experience the value of the refined regenerative medicine offered by Maison Prive Clinic.
Re2O Q&A
- Q1. What is the difference between Re2O and Re2O Fine?
A. The two products differ in particle size. Re2O is suitable for improving overall facial elasticity and skin texture, while Re2O Fine consists of finer particles, making it suitable for delicate treatment of thin and sensitive areas such as around the eyes and under the eyes. - Q2. When can the effects of Re2O be felt?
A. About 1 to 2 weeks after treatment, collagen regeneration is promoted and skin texture gradually becomes more refined. From 3 to 4 weeks onwards, you can begin to genuinely feel the changes as skin becomes firmer from within and overall condition turns healthier. - Q3. How long do the effects of Re2O last?
A. The effects of the Re2O skin booster generally last from 6 months to over a year. The duration you actually feel may vary depending on individual skin condition and the number of treatments. - Q4. How much pain does Re2O cause?
A. While there is individual variation, many find Re2O less painful than other skin booster treatments. Re2O is designed with a pH similar to the body's natural environment, so the stimulation felt during injection tends to be relatively mild. - Q5. Does the treatment affect daily life?
A. Slight bruising or swelling may occur at the treated area, but it usually subsides naturally within 5 to 7 days, allowing you to receive treatment without significant disruption to daily life. Recovery periods may vary by individual. - Q6. What are the precautions after treatment?
A. For one week after treatment, please avoid saunas, jjimjilbangs, strenuous physical activity, alcohol, and smoking, as these may irritate the skin. Take prescribed medications regularly to prevent inflammation, and pay extra attention to moisturizing care to keep the treated area from drying out.
